Tretinoin was the first topical retinoid to become available as treatment for acne vulgaris. This topical agent has been well established and widely accepted by the medical community since the 1970's. When a greater understanding of retinoid receptors was obtained in the late 1980's, the definition of this class expanded to include molecules that bind to and activate retinoid receptors. Tretinoin is available as a branded generic product in cream, gel and solution formulas, in concentrations ranging from .01% to .1%. Cream and gel formulations are generally administered once daily, at nighttime, and a pea sized amount is spread over the entire face.
Tretinoin Creams and other products absorb deeply to the skin even penetrating to the lower layers beneath the surface. Treatment with this topical retinoid cream eliminates the roughness of the skin. The skin cell turnover rate is increased with the regular use of tretinoin cream or gel. It also will produce continuous and efficient skin exfoliation, slowly removing the affected parts of the skin and gradually reducing the acne by reducing the comedones associated with acne and the pimples. Another advantage of tretinoin gels or creams is that they work to exfoliate blemishes and other sun damaged parts of your skin to smooth the surface and reduce photo aging or color blemishes. It has also been proven to reduce fine lines and wrinkles on the surface of the skin by producing more collagen within the skin.
Available branded topical tretinoin and retinoid products include:
- Retin-A Micro