Retin A (Tretinoin)
Cream .025%, .05%, .1%, 20 and 45 g
Gel .01%, .025%, 15 and 45 g
Solution .05%, 28 mL
Retin A Micro (Tetinoin)
Gel Microsphere .01%, .04%, 20 g and 45 g tubes, 50 g pumps
Retin-A has been available since the 1970's. It is provided by Johnson & Johnson. Since the introduction of generic forms of topical tretinoin and Retin-A Micro (tretinoin gel) microsphere, it has not been actively promoted. So much of the information provided here will refer to the newest Retin-A Micro formulation which many just lable as "Retin A".
Retin-A Micro is a tretinoin gel microsphere and was introduced in 1997. It is indicated for topical application in the treatment of acne vulgaris. It is administered once daily.
It is available in cream, gel and pump solution formulations. The cream formulations are available at .025%, .05%, .1% in 20 and 45 grams. The gel formulations are available in .01%, .025% in 15 and 45 gram tubes. The solution formulation comes packaged as a pump and is a .05% formulation consisting of 28mL.
Retin A Micro was designed as an advance over the original Retin A (tretinoin) formulation. This product uses a "microsponge" system to entrap tretinoin in microspheres. Microspheres are round microscopic particles made of synthetic polymers. The microspheres hold the medication for varying periods, which enables a gradual release of tretinoin into the skin over time.
The overall profile for this product is similar to that of other topical tretinoin products, but some differences have been noted. It provides tretinoin gel in a microsphere formulation which enables gradual release of tretinoin into the skin over time.
Retin A Micro can be applied immediately after patients wash their face, unlike some of the other tretinoin products which prefer a 20 - 30 minute waiting or drying period.
Off Label Use: Some forms of this medication are used to improve the appearance of the skin and minimize fine line wrinkles. This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional. Your doctor may also use this medication to treat other conditions.
Product labeling for this product states that the skin of certain individuals may become excessively dry, red, swollen, or blistered.
Other available branded topical tretinoin products and topical retinoid products include:
- Retin-A Micro