.1%, .3% Gel
Differin was introduced in 1996. It is available in .1% cream and gel formulations and a ..3% gel formulation all available in 45 g tubes. A .1% lotion formulation of Differin is available in a 2 oz bottle pump. The brand is marketed by Galderma Laboratories.
Generic adapalene .1% cream and gel formulations became available in 2010, when the patent for these formulations of Differin expired.
The general profile for this product and adapalene is similar to that of topical tretinoin products. However, some comparative studies have suggested that Differin or adapalene may produce less local irritation than topical tretinoin.
The reasons for these potential differences from tretinoin are not well understood. Some researchers have speculated that differences in mechanism of action may play a role. Meaning with greater selectivity for subtypes of retinoid receptors and varied effects on free fatty acids or inflammation. Other researchers have noted that only small amounts of adapalene are absorbed after topical application, and have suggested that this may play a role in its relatively low irritancy.
Off Label Use: Some forms of this medication are used to improve the appearance of the skin and minimize fine line wrinkles. This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional. Your doctor may also use this medication to treat other conditions.
Other available branded topical tretinoin products and topical retinoid products include:
- Retin-A Micro